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Article

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Apr 2015

Scotter Emma L, Chen Han-Jou, Shaw Christopher E

Abstract excerpt

Therapeutic options for patients with amyotrophic lateral sclerosis (ALS) are currently limited. However, recent studies show that almost all cases of ALS, as well as tau-negative frontotemporal dementia (FTD), share a common neuropathology characterized by the deposition of TAR-DNA binding protein (TDP)-43-positive protein inclusions, offering an attractive target for the design and testing of novel...

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Identifiers

PMID: 25652699
DOI: 10.1007/s13311-015-0338-x
PMCID: PMC4404432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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