Article

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

2023-09-26

Abstract excerpt

<title>Abstract</title> <p> TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic-acid binding protein TDP-43 and subsequent neuronal dysfunction. Here, we developed endogenous models of sporadic TDP-43 proteinopathy based on the principle that disease-associ...

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Literature Corpus work: 8d1eef63-8887-5927-92d0-608d6fb4fdbc
DOI: 10.21203/rs.3.rs-2200020/v5

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