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Article

Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Oct 2015

Jablonski Angela M, Lamitina Todd, Liachko Nicole F, Sabatella Mariangela, Lu Jiayin, Zhang Lei, Ostrow Lyle W, Gupta Preetika, Wu Chia-Yen, Doshi Shachee, Mojsilovic-Petrovic Jelena, Lans Hannes, Wang Jiou, Kraemer Brian, Kalb Robert G

Abstract excerpt

Misfolded proteins accumulate and aggregate in neurodegenerative disease. The existence of these deposits reflects a derangement in the protein homeostasis machinery. Using a candidate gene screen, we report that loss of RAD-23 protects against the toxicity of proteins known to aggregate in amyotrophic lateral sclerosis. Loss of RAD-23 suppresses the locomotor deficit of Caenorhabditis elegans engineered to...

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Identifiers

PMID: 26490867
DOI: 10.1523/JNEUROSCI.0642-15.2015
PMCID: PMC4683688

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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