Article

TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

2025-10-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Pathological TAR DNA-binding protein 43 (TDP-43) dysfunction is associated with multiple neurodegenerative disorders. However, the mechanistic link between TDP-43 dysfunction and neurodegeneration is poorly understood and likely involves a combination of genetic and environmental risk factors. A major risk factor for neurodegenerative disease is exposure to traumatic brain i...

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Literature Corpus work: 69dcd617-6d91-524a-9ec4-e85ef47e47cb
DOI: 10.1101/2025.10.20.683438

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