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Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration

2 Aug 2011

Abstract excerpt

Since the identification of phosphorylated and truncated transactive response DNA-binding protein 43 (TDP-43) as a primary component of ubiquitinated inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions, much effort has been directed towards ascertaining how TDP-43 contributes to the pathogenesis of disease. As with other protein misfolding...

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Amyotrophic Lateral Sclerosis Research
Neurogenetic and Muscular Disorders Research
Parkinson's Disease Mechanisms and Treatments

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PMID: 21811811
DOI: 10.1007/s12031-011-9610-7

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Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated NeurodegenerationPMID 21811811Read ↗

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