Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TDP-43 post-translational modifications in health and disease

10 Feb 2018

Abstract excerpt

INTRODUCTION: Nuclear factor TDP-43 is a ubiquitously expressed RNA binding protein that plays a key causative role in several neurodegenerative diseases, especially in the ALS/FTD spectrum. In addition, its aberrant aggregation and expression has been recently observed in other type of diseases, such as myopathies and Niemann-Pick C, a lysosomal storage disease. Areas covered: This review aims to specifically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Histone Deacetylase Inhibitors Research
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29431050
DOI: 10.1080/14728222.2018.1439923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TDP-43 post-translational modifications in health and diseasePMID 29431050Read ↗

TDP-43 Epigenetic Facets and Their Neurodegenerative ImplicationsSemantic proximity Read ↗

Decoding TDP-43: the molecular chameleon of neurodegenerative diseasesSemantic proximity Read ↗

Structural Insights Into TDP-43 and Effects of Post-translational ModificationsSemantic proximity Read ↗

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.Semantic proximity Read ↗

Molecular, functional, and pathological aspects of TDP-43 fragmentationSemantic proximity Read ↗

Functional Significance of TDP-43 Mutations in Disease.Semantic proximity Read ↗

TDP-43 proteinopathies: a new wave of neurodegenerative diseasesSemantic proximity Read ↗

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteinsSemantic proximity Read ↗

Proteomics Analysis of the TDP ‐43 Interactome in Cellular Models of ALS PathogenesisSemantic proximity Read ↗

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders.Semantic proximity Read ↗

TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: From pathomechanisms to therapeutic strategiesSemantic proximity Read ↗

Unraveling the toxic effects mediated by the neurodegenerative disease-associated S375G mutation of TDP-43 and its S375E phosphomimetic variant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.