Article

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice

2024-09-14

Abstract excerpt

Protein misfolding and aggregation are cardinal features of neurodegenerative disease (NDD) and they contribute to pathophysiology by both loss-of-function (LOF) and gain-of-function (GOF) mechanisms. This is well exemplified by TDP-43 which aggregates and mislocalizes in several NDDs. The depletion of nuclear TDP-43 leads to reduction in its normal function in RNA metabolism and the cytoplasmic accumulation of TD...

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Literature Corpus work: 66654ae3-4594-53b2-9361-0048a2694f40
DOI: 10.1101/2024.09.10.612226

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