Article

Targeting succinate-driven microglial metabolic reprogramming alleviates neuroinflammation after cerebral ischemia–reperfusion

2026-06-23

Abstract excerpt

<title>Abstract</title> <p>Background: Ischemic stroke triggers profound metabolic disturbance and oxidative stress following ischemia–reperfusion, driving secondary neuroinflammation and neuronal injury. Succinate rapidly accumulates under ischemic conditions, yet its active role and receptor-mediated mechanisms in post-stroke inflammation remain unclear. <h4>Methods:</h4> We integrated targeted metabolomics, c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90f37f6b-cb03-5a0b-94a3-37c8c637c95a
DOI: 10.21203/rs.3.rs-9985262/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting succinate-driven microglial metabolic reprogramming alleviates neuroinflammation after cerebral ischemia–reperfusionDOI 10.21203/rs.3.rs-9985262/v1Read

Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammationSemantic proximity Read

Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism.Semantic proximity Read

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.Semantic proximity Read

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system.Semantic proximity Read

Exploring the key role of neuroinflammation in the formation of delayed encephalopathy after acute carbon monoxide poisoning based on multi-omics and snRNA-seqSemantic proximity Read

The Impact of Environmental Enrichment on Neurological Damage: Mechanistic Study of Ferroptosis Inhibition via Tlr4Semantic proximity Read

NAD+ Improves Cognitive Function and Reduces Neuroinflammation By Ameliorating Mitochondrial Damage and Decreasing ROS Production in Chronic Cerebral Hypoperfusion Models Through Sirt1/PGC-1α PathwaySemantic proximity Read

Astragaloside IV alleviates neuronal ferroptosis in ischemic stroke by regulating FTO-m6A-ACSL4 axisSemantic proximity Read

Tweaking energy metabolism to prevent and treat neurological disorders.Semantic proximity Read

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC-Derived Microglia and Modulates Glial–Neuronal CrosstalkSemantic proximity Read

The pathogenic role of Succinate-SUCNR1: A critical function that induces renal fibrosis via infiltration of M2 macrophageSemantic proximity Read