Article

Improving Cardiac Resilience to Ischemia/Reperfusion: The Role of Butyrate in Mitochondrial and Metabolic Recovery

2025-06-27

Abstract excerpt

<h4>Background</h4> Cardiac transplantation is limited by a persistent shortage of donor organs. While hearts donated after circulatory death (DCD) could expand donors pool, their use is hindered by high rates of primary graft dysfunction (PGD) due to ischemia/reperfusion (I/R)-induced metabolic injury. Here, we investigate the therapeutic potential of the short-chain fatty acid butyrate (BT) to restore metabolic...

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Literature Corpus work: fcd4f44e-fc37-558e-b046-2fe6f54d7a04
DOI: 10.1101/2025.06.23.661163

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