Lactylation landscape of mitochondrial proteins in myocardial infarction

Abstract excerpt

Metabolic reprogramming is a hallmark of myocardial infarction (MI), in which cardiomyocytes shift from fatty acid oxidation to anaerobic glycolysis, leading to elevated lactate production and mitochondrial dysfunction. Lactylation, a recently described lysine post-translational modification, has emerged as a metabolic signaling mechanism; however, its role within mitochondria during MI remains poorly understood....

Topics

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• Adipose Tissue and Metabolism
• ATP Synthase and ATPases Research
• Cancer, Hypoxia, and Metabolism
• Cardiovascular Function and Risk Factors
• Diet and metabolism studies
• Liver Disease Diagnosis and Treatment
• Liver physiology and pathology
• Mitochondrial Function and Pathology

Identifiers and source

Literature Corpus work

a68fb1ee-876f-5372-b54a-a01f08409e92

DOI

10.64898/2026.04.27.718938