PDK4-Mediated VDAC2 Lactylation Links Glycolysis to Autophagy Failure in Septic Cardiomyopathy

Abstract excerpt

<h4>Background</h4> Elevated lactate is a critical prognostic biomarker in sepsis, strongly associated with increased mortality. Sepsis-induced cardiomyopathy (SICM) is a major contributor to poor outcomes in septic patients, yet the mechanisms linking lactate elevation to SICM pathogenesis remain incompletely understood. <h4>Methods</h4> We combined experimental murine models of sepsis with patient cohort analy...

Topics

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• Cardiomyopathies
• Energy Metabolism
• Epigenesis, Genetic
• Hyperglycemia and glycemic control in critically ill and hospitalized patients
• Metabolomics and Mass Spectrometry Studies
• Phenotype
• Sepsis
• Sepsis Diagnosis and Treatment

Identifiers and source

Literature Corpus work

3196e7d3-d731-5eca-b2e2-b8dde6280437

DOI

10.1101/2025.09.22.25336402