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Posttranslational modifications optimize the ability of SARS-CoV-2 spike for effective interaction with host cell receptors

23 Jun 2022

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein is the prime target for vaccines, diagnostics, and therapeutic antibodies against the virus. While anchored in the viral envelope, for effective virulence, the spike needs to maintain structural flexibility to recognize the host cell surface receptors and bind to them, a property that can heavily depend upon the dynamics of the...

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PMID: 35737823
DOI: 10.1073/pnas.2119761119

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