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Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein

17 Jul 2020

Abstract excerpt

Global emergencies caused by the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle-East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV-2 significantly endanger human health. The spike (S) glycoprotein is the key antigen and its conserved S2 subunit contributes to viral entry by mediating host-viral membrane fusion. However, structural information of the post-fusion S2 from these highly...

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PMID: 32681106
DOI: 10.1038/s41467-020-17371-6

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