Article

Secretome of senescent hepatoma cells modulate macrophage polarization and neutrophil extracellular traps formation

2021-01-02

Abstract excerpt

Presence of dysfunctional senescent hepatocyte is a hallmark feature of cirrhosis. We now report the presence of senescent hepatocytes (p21 and p53 positive) in vicinity of infiltrated immune cells in hepatocellular carcinoma. Hence, we checked if senescent cells can alter fate of macrophage polarization and neutrophil extracellular trap (NETs) formation. Using an in vitro assay, senescence was induced in hepatoma...

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Literature Corpus work: fcc0f9f5-f59d-505b-b359-adb992378435
DOI: 10.1101/2020.12.30.423905

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