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Article

Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis.

Cell reports - 28 Feb 2023

Admasu Tesfahun Dessale, Kim Kristie, Rae Michael, Avelar Roberto, Gonciarz Ryan L, Rebbaa Abdelhadi, Pedro de Magalhães João, Renslo Adam R, Stolzing Alexandra, Sharma Amit

Abstract excerpt

Senescent cells can spread the senescent phenotype to other cells by secreting senescence-associated secretory phenotype factors. The resulting paracrine senescent cells make a significant contribution to the burden of senescent cell accumulation with age. Previous efforts made to characterize paracrine senescence are unreliable due to analyses being based on mixed populations of senescent and non-senescent...

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Identifiers

PMID: 36753419
DOI: 10.1016/j.celrep.2023.112058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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