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Article

Role of Clusterin/NF-κB in the secretion of senescence-associated secretory phenotype in Cr(VI)-induced premature senescent L-02 hepatocytes.

Ecotoxicology and environmental safety - 1 Aug 2021

Liang Yuehui, Liang Ningjuan, Ma Yu, Tang Sixuan, Ye Shuzi, Xiao Fang

Abstract excerpt

Hexavalent chromium [Cr(VI)] and its compounds have caused serious environmental pollution and health damage. Senescent cells can actively change the surrounding environment by secreting some factors, which are called senescence associated secretory phenotype (SASP). Our previous work has confirmed that premature senescent hepatocytes induced by Cr(VI) expressed high level of Clusterin (CLU) and secrete...

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PMID: 34020271
DOI: 10.1016/j.ecoenv.2021.112343

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