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Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

2 Apr 2012

Abstract excerpt

Cellular senescence, a state of stable growth arrest, can occur in response to various stress stimuli such as telomere shortening, treatment with chemotherapeutic drugs or the aberrant activation of oncogenes. Senescent cells communicate with their environment by secreting various cytokines and growth factors, and it has become clear that this 'secretory phenotype' can have pro- as well as anti-tumorigenic...

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Share to Cytomegalovirus and herpesvirus research
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 22470164
DOI: 10.1093/carcin/bgs124

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