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Similarities and interplay between senescent cells and macrophages

23 Dec 2020

Abstract excerpt

Senescence is a cellular program that prevents the replication of old, damaged, or cancerous cells. Senescent cells become growth arrested and undergo changes in their morphology, chromatin organization, and metabolism, and produce a bioactive secretome. This secretome, the senescence-associated secretory phenotype (SASP), mediates many of the pathophysiological effects associated with senescent cells, for...

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PMID: 33355620
DOI: 10.1083/jcb.202010162

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