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Article

Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis.

Journal of hepatology - 1 Aug 2010

Sasaki Motoko, Miyakoshi Masami, Sato Yasunori, Nakanuma Yasuni

Abstract excerpt

BACKGROUND & AIMS: Biliary epithelial cells (BECs) in damaged small bile ducts in primary biliary cirrhosis (PBC) show senescent features. Given that senescent cells modulate the microenvironment by expressing senescence-associated secretory phenotypes (SASP), including inflammatory cytokines and...

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Source

Identifiers

PMID: 20570384
DOI: 10.1016/j.jhep.2010.03.008

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20570384-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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