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Article

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration.

World journal of gastroenterology - 21 Dec 2014

Irvine Katharine M, Skoien Richard, Bokil Nilesh J, Melino Michelle, Thomas Gethin P, Loo Dorothy, Gabrielli Brian, Hill Michelle M, Sweet Matthew J, Clouston Andrew D, Powell Elizabeth E

Abstract excerpt

AIM: To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype (SASP). METHODS: Hydrogen peroxide treatment was used to induce senescence in the human HepG2 hepatocyte cell line. Senescence was confirmed by cytochemical staining for a panel of markers including Ki67, p21, heterochromatin protein 1β, and senescence-associated-β-galactosidase activity....

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Identifiers

PMID: 25548483
DOI: 10.3748/wjg.v20.i47.17851
PMCID: PMC4273135

Genes

SAA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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