Article

Activation of Nedd4L Ubiquitin Ligase by FCHO2-generated Membrane Curvature

2022-02-22

Abstract excerpt

<h4>SUMMARY</h4> The C2-WW-HECT domain ubiquitin ligase Nedd4L regulates sorting in endocytosis by mediating ubiquitination of cargo molecules, such as the epithelial sodium channel (ENaC). Defects in ENaC ubiquitination cause Liddle syndrome, a hereditary hypertension. Nedd4L is catalytically autoinhibited by an intramolecular interaction between the C2 and HECT domains, but the activation mechanism is poorly un...

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Literature Corpus work: fcc0d7e7-a7cd-5795-a207-83abc7508d0d
DOI: 10.1101/2022.02.21.481372

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