Article
BAR domains as sensors of membrane curvature: the amphiphysin BAR structure.
Science (New York, N.Y.) - 23 Jan 2004
Peter Brian J, Kent Helen M, Mills Ian G, Vallis Yvonne, Butler P Jonathan G, Evans Philip R, McMahon Harvey T
Abstract excerpt
The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain. It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes. With its N-terminal amphipathic helix and BAR domain (N-BAR), amphiphysin can drive membrane...
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