Article

Argininosuccinate Synthase 1 links hepatic urea cycle to whole body lipid metabolism

2026-06-03

Abstract excerpt

The hepatic urea cycle is consistently suppressed in liver disease and hepatocellular carcinoma (HCC), but whether loss of individual enzymes contributes to disease initiation and progression remains unknown. Using mice with hepatocyte-specific deletion of argininosuccinate synthase 1 (ASS1), the urea cycle enzyme that condenses citrulline and aspartate into argininosuccinate, we investigated the role of ASS1 in d...

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Literature Corpus work: fcbc226e-4fe0-53b8-a1f0-7e20d1e7208c
DOI: 10.64898/2026.06.02.729618

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