Article

Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate

2024-10-17

Abstract excerpt

<h4> Abstract </h4> The progression of metabolic-dysfunction-associated steatotic liver disease (MASLD) to metabolic-dysfunction-associated steatohepatitis (MASH) involves complex alterations in both liver-autonomous and systemic metabolism that influence the liver’s balance of fat accretion and disposal. Here, we quantify the relative contribution of hepatic oxidative pathways to liver injury in MASLD-MASH. Usi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c6facda-a969-5091-b179-4cbe89a07489
DOI: 10.1101/2024.10.17.618895

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rateDOI 10.1101/2024.10.17.618895Read

Metabolic Rewiring in MASLD: From Disease Mechanisms to Precision MedicineSemantic proximity Read

Hepatic ketogenesis regulates lipid homeostasis via ACSL1-mediated fatty acid partitioningSemantic proximity Read

Hepatic Ketogenesis Attenuates Cardiac Hypertrophy via Metabolic ReprogrammingSemantic proximity Read

Mitochondrial fatty acid synthesis is essential for coordinated energy transformationSemantic proximity Read

Human-Mouse Convergence in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mouse Model Selection and Non-Invasive Diagnostic StrategiesSemantic proximity Read

Humanized diet and thermoneutral housing enable sex-aware dissection of the MASLD-T2D-CVD triadSemantic proximity Read

A Translational Model of MASLD-Associated HFpEF Defines Mitochondrial Dysfunction and Cardiac Plasticity During Disease Progression and RegressionSemantic proximity Read

Chronic alcohol intake elicits distinct multi-omic profiles in the liver <i>versus</i> skeletal muscle of miceSemantic proximity Read

Mitochondrial Dysfunction Induces Hepatic Lipid Accumulation and Inflammatory Responses in mtDNA Mutator MiceSemantic proximity Read

Inter-Organ Crosstalk in MASLD: A Narrative ReviewSemantic proximity Read

Time-restricted feeding exacerbates liver fibrosis by promoting BDH1-mediated ketolysis in hepatic stellate cellsSemantic proximity Read

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolismSemantic proximity Read