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Article

High salt supplementation of a MASH-inducing diet causes lean MASH phenotype with increased hepatic urea cycle activity and EIF5A hypusination.

Molecular metabolism - 1 Sept 2026

Luo Shaopeiwen, Morisawa Norihiko, Widjaja Anissa Anindya, Singh Brijesh Kumar, Hausenloy Derek John, Yen Paul Michael, Zhou Jin

Abstract excerpt

BACKGROUND: MASLD/MASH can occur in lean individuals; however, the environmental triggers and molecular mechanisms underlying lean MASH are unclear, and suitable animal models are lacking. RESULTS: Mice fed a Western diet with liquid fructose (WDF) develops obesity and MASH (obese MASH). In contrast, high salt supplementation of WDF (HSWDF) produced a lean MASH phenotype with reduced steatosis but induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42419570
DOI: 10.1016/j.molmet.2026.102417
PMCID: PMC13400288

Genes

EIF5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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High salt supplementation of a MASH-inducing diet causes lean MASH phenotype with increased hepatic urea cycle activity and EIF5A hypusination.PMID 42419570Read ↗

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