Article

Suppression of hepatic amino acid catabolism by the human-specific lncRNA hLMR1

2025-11-08

Abstract excerpt

Amino acid (AA) catabolism and ureagenesis in the liver are essential for maintaining systemic nitrogen homeostasis. Patients with metabolic-associated fatty liver disease (MAFLD) exhibit impaired hepatic AA catabolism and urea production, accompanied by repression of genes governing these pathways. The molecular basis of this repression remains unknown. Here, we identify the hepatocyte-specific long noncoding RNA...

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Literature Corpus work: c90bf6c2-0e2b-5bca-8af4-83eceb266818
DOI: 10.1101/2025.11.08.686969

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