Article
Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis.
Cell death & disease - 1 Oct 2021
van der Meer Jonathan H M, de Boer Ruben J, Meijer Bartolomeus J, Smit Wouter L, Vermeulen Jacqueline L M, Meisner Sander, van Roest Manon, Koelink Pim J, Dekker Evelien, Hakvoort Theodorus B M, Koster Jan, Hawinkels Lukas J A C, Heijmans Jarom, Struijs Eduard A, Boermeester Marja A, van den Brink Gijs R, Muncan Vanesa
Abstract excerpt
The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS1 leads to de novo synthesis of arginine, an important amino acid for the growth of intestinal epithelial cells, its upregulation can contribute to epithelial proliferation...
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