Article
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
DNA repair - 1 Dec 2022
Carracedo Sergio, Lirussi Lisa, Alsøe Lene, Segers Filip, Wang Changliang, Bartosova Zdenka, Bohov Pavol, Tekin Nuriye B, Kong Xiang Yi, Esbensen Q Ying, Chen Liang, Wennerström Anna, Kroustallaki Penelope, Ceolotto Deborah, Tönjes Anke, Berge Rolf Kristian, Bruheim Per, Wong Garry, Böttcher Yvonne, Halvorsen Bente, Nilsen Hilde
Abstract excerpt
Fatty liver diseases are a major health threat across the western world, leading to cirrhosis and premature morbidity and mortality. Recently, a correlation between the base excision repair enzyme SMUG1 and metabolic homeostasis was identified. As the molecular mechanisms remain unknown, we exploited a SMUG1-knockout mouse model to gain insights into this association by characterizing the liver phenotype in young...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.