Article

Daple-FLT3 (CCDC88C-FLT3) gene fusion requires the coiled-coil domain for maximal activation and pericentrosomal localization

2025-09-29

Abstract excerpt

Gene fusions are stable protein products often occurring from chromosomal rearrangements. These chimeric proteins typically contain distinct molecular entities from each parent gene, and thus, create a product with altered or aberrant function. Gene fusions are frequently found in cancers, including Leukemia. Here, we characterize the kinase activity and subcellular distribution of the Daple-FLT3 (CCDC88C-FLT3) fu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fcba8e5d-c6d2-5664-8eb0-af6b5e67e579
DOI: 10.1101/2025.09.25.678166

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Daple-FLT3 (CCDC88C-FLT3) gene fusion requires the coiled-coil domain for maximal activation and pericentrosomal localizationDOI 10.1101/2025.09.25.678166Read

FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human GlioblastomaSemantic proximity Read

Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapiesSemantic proximity Read

CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal nicheSemantic proximity Read

Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.Semantic proximity Read

FUS::DDIT3 Fusion Protein in the Development of Myxoid Liposarcoma and Possible Implications for TherapySemantic proximity Read

CCDC6: the identity of a protein known to be partner in fusion.Semantic proximity Read

CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profilesSemantic proximity Read

FGFR1 is fused to the centrosome-associated proteinCEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)Semantic proximity Read

IGF2BP3 is a key regulator for the abundance of t(4;11) fusion mRNA and proteinSemantic proximity Read

A novel peptide that disrupts the Lck-IP3R protein-protein interaction induces widespread cell death in leukemia and lymphomaSemantic proximity Read

Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.Semantic proximity Read

DAPk Protein Family and CancerSemantic proximity Read