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Article

Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.

Cancer research - 15 Apr 2011

Brognard John, Zhang You-Wei, Puto Lorena A, Hunter Tony

Abstract excerpt

Cancer kinome sequencing studies have identified several protein kinases predicted to possess driver (i.e., causal) mutations. Using bioinformatic applications, we have pinpointed DAPK3 (ZIPK) as a novel cancer-associated kinase with functional mutations. Evaluation of nonsynonymous point mutations, discovered in DAPK3 in various tumors (T112M, D161N, and P216S), reveals that all three mutations decrease or...

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Source

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Identifiers

PMID: 21487036
DOI: 10.1158/0008-5472.CAN-10-3543
PMCID: PMC3078168

Genes

DAPK3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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