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Article

Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.

The Journal of biological chemistry - 27 Nov 2009

Han Yanyan, Eppinger Elfriede, Schuster Ingrid G, Weigand Luise U, Liang Xiaoling, Kremmer Elisabeth, Peschel Christian, Krackhardt Angela M

Abstract excerpt

The formin protein formin-like 1 (FMNL1) is highly restrictedly expressed in hematopoietic lineage-derived cells and has been previously identified as a tumor-associated antigen. However, function and regulation of FMNL1 are not well defined. We have identified a novel splice variant (FMNL1gamma) containing an intron retention at the C terminus affecting the diaphanous autoinhibitory domain (DAD). FMNL1gamma is...

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Identifiers

PMID: 19815554
DOI: 10.1074/jbc.M109.060699
PMCID: PMC2785185

Genes

FMNL1

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