Article

IGF2BP3 is a key regulator for the abundance of t(4;11) fusion mRNA and protein

2026-01-21

Abstract excerpt

<title>Abstract</title> <p>The chromosomal translocation t(4;11)(q21;q23) is the most frequently diagnosed genetic aberration in KMT2A-r acute leukemia patients. Although we understand the molecular functions of both wildtype KMT2A and AFF1 multiprotein complexes, little is known about the interplay between the fusion proteins KMT2A::AFF1 (MA4) and AFF1::KMT2A (A4M). Here, we established model systems to investig...

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Literature Corpus work: 3ad8b009-86ab-5c6f-a072-3eb6192b4faa
DOI: 10.21203/rs.3.rs-8602907/v1

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