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CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles

14 Aug 2017

Abstract excerpt

Pediatric low-grade gliomas (PLGGs) are commonly associated with BRAF gene fusions that aberrantly activate the mitogen-activated protein kinase (MAPK) signaling pathway. This has led to PLGG clinical trials utilizing RAF- and MAPK pathway-targeted therapeutics. Whole-genome profiling of PLGGs has also identified rare gene fusions involving another RAF isoform, CRAF/RAF1, in PLGGs and cancers occuring in adults....

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PMID: 28806393
DOI: 10.1038/onc.2017.276

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