Article

A novel peptide that disrupts the Lck-IP3R protein-protein interaction induces widespread cell death in leukemia and lymphoma

2023-01-09

Abstract excerpt

<title>Abstract</title> <p>There is increasing evidence that the T-cell protein, Lck, is involved in the pathogenesis of chronic lymphocytic leukemia (CLL) as well as other leukemias and lymphomas. We previously discovered that Lck binds to domain 5 of inositol 1,4,5-trisphosphate receptors (IP3R) to regulate Ca2+ homeostasis. Using bioinformatics, we targeted a region within domain 5 of IP3R-1 predicted to facil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb6f7dd7-2df3-53bb-9f4e-5b50e20df281
DOI: 10.21203/rs.3.rs-2436910/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel peptide that disrupts the Lck-IP3R protein-protein interaction induces widespread cell death in leukemia and lymphomaDOI 10.21203/rs.3.rs-2436910/v1Read

FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T cell lymphoma, not otherwise specifiedSemantic proximity Read

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specifiedSemantic proximity Read

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3BSemantic proximity Read

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy.Semantic proximity Read

LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities.Semantic proximity Read

Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitorsSemantic proximity Read

Peptide tiling across viral proteomes identifies modular regulators of stress-induced cell deathSemantic proximity Read

STAT1 Promotes PD-L1 Activation and Tumor Growth in LymphangioleiomyomatosisSemantic proximity Read

A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.Semantic proximity Read

The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.Semantic proximity Read

Pathogenic mutations of human phosphorylation sites affect protein-protein interactionsSemantic proximity Read

Pathogenic mutations of human phosphorylation sites affect protein-protein interactions.Semantic proximity Read