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Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies

19 Aug 2011

Abstract excerpt

Tyrosine kinase fusion genes represent an important class of oncogenes associated with leukaemia and solid tumours. They are produced by translocations and other chromosomal rearrangements of a subset of tyrosine kinase genes, including ABL, PDGFRA, PDGFRB, FGFR1, SYK, RET, JAK2 and ALK. Based on recent findings, this review discusses the common mechanisms of activation of these fusion genes. Enforced...

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PMID: 21854543
DOI: 10.1111/j.1582-4934.2011.01415.x

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