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Article

FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human Glioblastoma

4 Aug 2022

Abstract excerpt

Oncogenic fusion genes have emerged as successful targets in several malignancies, such as chronic myeloid leukemia and lung cancer. Fusion of the fibroblast growth receptor 3 and the transforming acidic coiled coil containing protein-FGFR3-TACC3 fusion-is prevalent in 3-4% of human glioblastoma. The fusion protein leads to the constitutively activated kinase signaling of FGFR3 and thereby promotes cell...

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PMID: 35955806
DOI: 10.3390/ijms23158675

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