Article

Effector T Cells under Hypoxia have an Altered Transcriptome Similar to Tumor-Stressed T Cells Found in Non-Responsive Melanoma Patients

2024-09-30

Abstract excerpt

<h4>Background</h4> In the Tumor Microenvironment (TME), hypoxia stands as a significant factor that modulates immune responses, especially those driven by T cells. As T cell-based therapies often fail to work in solid tumors, this study aims to investigate the effects of hypoxia on T cell topo-distribution in the TME, gene expression association with T cell states, and clinical responses in melanoma. <h4>Methods...

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Literature Corpus work: fcaf86c9-6db5-51cf-a4a3-3f06bfb5b350
DOI: 10.1101/2024.09.27.615474

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