Article

Cellular and spatial continuum of TAM functional states governs immune exclusion and dictates immune checkpoint resistance in melanoma

2026-06-03

Abstract excerpt

<title>Abstract</title> <p> Background Immune checkpoint inhibitor (ICI) therapy has transformed melanoma treatment, yet many patients either fail to respond or develop resistance after an initial response. The cellular and spatial determinants within the tumor microenvironment (TME) that underlie these divergent ICI therapy outcomes remain poorly defined. Here, we aimed to characterize the immune composition a...

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Literature Corpus work: 8a4b7467-323f-54bc-b4c3-97fe83f878ec
DOI: 10.21203/rs.3.rs-9692259/v1

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