Article
In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response.
Nature communications - 9 Sept 2022
Sahu Aditi, Kose Kivanc, Kraehenbuehl Lukas, Byers Candice, Holland Aliya, Tembo Teguru, Santella Anthony, Alfonso Anabel, Li Madison, Cordova Miguel, Gill Melissa, Fox Christi, Gonzalez Salvador, Kumar Piyush, Wang Amber Weiching, Kurtansky Nicholas, Chandrani Pratik, Yin Shen, Mehta Paras, Navarrete-Dechent Cristian, Peterson Gary, King Kimeil, Dusza Stephen, Yang Ning, Liu Shuaitong, Phillips William, Guitera Pascale, Rossi Anthony, Halpern Allan, Deng Liang, Pulitzer Melissa, Marghoob Ashfaq, Chen Chih-Shan Jason, Merghoub Taha, Rajadhyaksha Milind
Abstract excerpt
Response to immunotherapies can be variable and unpredictable. Pathology-based phenotyping of tumors into 'hot' and 'cold' is static, relying solely on T-cell infiltration in single-time single-site biopsies, resulting in suboptimal treatment response prediction. Dynamic vascular events (tumor angiogenesis, leukocyte trafficking) within tumor immune microenvironment (TiME) also influence anti-tumor immunity and...
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