Article

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanoma

2025-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Intra-tumoral heterogeneity in melanoma arises from dynamic cancer cell plasticity and underlies various mechanisms of immune escape. Here, we combined high-plex immunofluorescence imaging with spatially resolved transcriptomics to map the architecture of melanoma cell states and their interactions with the immune microenvironment in primary cutaneous tumours prior to adjuvant anti-PD1 immune ch...

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Literature Corpus work: fd58b483-8d7b-5881-bfe0-7e8ff4b91bff
DOI: 10.1101/2025.07.07.661465

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