Article

Unraveling the Single-Cell Spatial Landscapes of Melanoma Brain Metastases

2025-09-02

Abstract excerpt

<h4>Summary</h4> The cellular composition of the tumor ecosystem is a critical determinant of therapeutic responsiveness to immune checkpoint inhibitors (ICi) and BRAF inhibitors (BRAFi). However, the specific compositional dynamics that drive the subsequent progression of melanoma brain metastases (MBMs) remain poorly understood. Here, we performed single cell-resolved spatial transcriptomics profiling of multip...

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Literature Corpus work: 468b8aa8-9a17-52a5-a000-26d780221cce
DOI: 10.1101/2025.08.29.25334740

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