Back to search

Article

Integrated Spatial Multi-omic Profiling Identifies HSV-associated Inflammatory Macrophage Niches Linked to Oncolytic Virotherapy Response in Melanoma

2026-05-21

Abstract excerpt

<h4>Background</h4> Primary and secondary resistance to immune checkpoint blockade (ICB) remains a critical challenge in advanced melanoma. Oncolytic Viruses (OV) selectively lyse tumor cells while generating systemic anti-tumor immune responses with minimal side effects. Yet their clinical use is limited to refractory melanoma patients and are only given in combination with second-line ICB regimens. ICB can both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3edf403c-0a6c-5631-9117-ffc7d108b14c
DOI
10.64898/2026.05.20.726697
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrated Spatial Multi-omic Profiling Identifies HSV-associated Inflammatory Macrophage Niches Linked to Oncolytic Virotherapy Response in MelanomaDOI 10.64898/2026.05.20.726697
Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanomaSemantic proximity
Cellular and spatial continuum of TAM functional states governs immune exclusion and dictates immune checkpoint resistance in melanomaSemantic proximity
Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma.Semantic proximity
Unraveling the Single-Cell Spatial Landscapes of Melanoma Brain MetastasesSemantic proximity
Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden.Semantic proximity
Population analysis and immunologic landscape of melanoma in people living with HIV indicate impaired antitumor immunitySemantic proximity
A cross-scale multimodal framework identifies clinically actionable immunotherapy biomarkers in melanoma through bulk to single-cell and spatial transcriptomics integrationSemantic proximity
Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanomaSemantic proximity
Mapping the Immune Landscape in Metastatic Melanoma Reveals Localized Cell–Cell Interactions That Predict Immunotherapy ResponseSemantic proximity
Mapping the immune landscape in metastatic melanoma reveals localized cell-cell interactions correlating to immunotherapy responsivenessSemantic proximity
Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments linked to immunotherapy responses in melanomaSemantic proximity
Single-cell analysis reveals new evolutionary complexity in uveal melanomaSemantic proximity
Select a neighboring publication to make it the new centre.