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HDACs in the Brain: From Chromatin Remodeling to Neurodegenerative Disease

29 Aug 2025

Abstract excerpt

Histone deacetylases (HDACs) are key epigenetic regulators that influence chromatin remodeling, gene expression, and cellular plasticity in the central nervous system (CNS). This review provides a comprehensive overview of the classification and functional diversity of HDACs, with particular emphasis on their roles in neural progenitor cells, mature neurons, and glial populations. In neural stem and progenitor...

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Cholinesterase and Neurodegenerative Diseases
Epigenetics and DNA Methylation
Histone Deacetylase Inhibitors Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40940748
DOI: 10.3390/cells14171338

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