Article
Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome.
EBioMedicine - 1 Jun 2024
Tsang Erica, Han Velda X, Flutter Chloe, Alshammery Sarah, Keating Brooke A, Williams Tracey, Gloss Brian S, Graham Mark E, Aryamanesh Nader, Pang Ignatius, Wong Melanie, Winlaw David, Cardamone Michael, Mohammad Shekeeb, Gold Wendy, Patel Shrujna, Dale Russell C
Abstract excerpt
BACKGROUND: Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression. Ketones, derived from the ketogenic diet, are histone deacetylase inhibitors that can 'open' chromatin and encourage gene expression. Preclinical studies have shown that the...
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