Article

Proteolytic processing of Argonautes in multiphase condensates promotes transgenerational epigenetic inheritance

2026-01-02

Abstract excerpt

<h4>Summary</h4> Epigenetic information can be memorized in perinuclear condenates to transmit across generations to modulate gene expression in descenent. Here, we identify a conserved N terminal proteolytic mechanism in Caenorhabditis elegans that is essential for small RNA-mediated transgenerational epigenetic inheritance (TEI) and for maintaining germline immortality. Two conserved, perinuclear germ granule...

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Literature Corpus work: 33d8d35d-52c0-5487-bd0c-522165a7fa2b
DOI: 10.64898/2026.01.01.697165

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