Article

RG motifs promote piRNA-mediated gene silencing in <i>C. elegans</i>

2025-05-15

Abstract excerpt

Argonaute proteins are essential players in RNA silencing pathways, and their N-terminal extensions, particularly in the PIWI clade, often harbor conserved sequences like RG motifs. Despite their prevalence in Argonaute proteins, the role of these motifs remains poorly understood. In this study, we focus on the RG motifs within the N-terminal region of Caenorhabditis elegans PRG-1, a PIWI clade Argonaute. Using s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51f5b7d6-fb3f-57b3-8e28-f8dfa28e8e7e
DOI: 10.1101/2025.05.12.653514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RG motifs promote piRNA-mediated gene silencing in <i>C. elegans</i>DOI 10.1101/2025.05.12.653514Read

PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans.Semantic proximity Read

The Ubiquitin-Proteasome Pathway Mediates Selective Degradation of Unloaded Argonautes in <i>C. elegans</i>Semantic proximity Read

The USTC complex co-opts an ancient machinery to drive piRNA transcription in <i>C. elegans</i>Semantic proximity Read

Biogenesis of mature piRNAs in <i>Caenorhabditis elegans</i> is dependent on orchestration between multiple ribonucleases and PRG-1Semantic proximity Read

The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in <i>C. elegans</i>Semantic proximity Read

The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.Semantic proximity Read

Identification of piRNA binding sites reveals the Argonaute regulatory landscape of the <i>C. elegans</i> germlineSemantic proximity Read

Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA InheritanceSemantic proximity Read

The RNA Polymerase II core subunit RPB-9 directs transcriptional elongation at piRNA loci in <i>Caenorhabditis elegans</i>Semantic proximity Read

Somatic function of the Argonaute protein Aubergine is essential for neuromuscular development and function in <i>Drosophila</i>Semantic proximity Read

PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans.Semantic proximity Read

hnRNPA1/2 homolog <i>hrpa-1</i> coordinates with miRNAs to regulate gene expression during <i>C. elegans</i> developmentSemantic proximity Read