Article

Protease-mediated processing of Argonaute proteins controls small RNA association

2020-12-09

Abstract excerpt

<h4>Summary</h4> Small RNA pathways defend the germlines of animals against selfish genetic elements and help to maintain genomic integrity. At the same time, their activity needs to be well-controlled to prevent silencing of ‘self’ genes. Here, we reveal a proteolytic mechanism that controls endogenous small interfering (22G) RNA activity in the Caenorhabditis elegans germline to protect genome integrity and ma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0746ffbd-9526-5b9a-a96e-22e92bb83270
DOI: 10.1101/2020.12.09.417253

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protease-mediated processing of Argonaute proteins controls small RNA associationDOI 10.1101/2020.12.09.417253Read

Proteolytic processing of Argonautes in multiphase condensates promotes transgenerational epigenetic inheritanceSemantic proximity Read

Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.Semantic proximity Read

The Ubiquitin-Proteasome Pathway Mediates Selective Degradation of Unloaded Argonautes in <i>C. elegans</i>Semantic proximity Read

Crosstalk between and developmental dynamics of <i>C. elegans</i> Argonaute proteinsSemantic proximity Read

Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA InheritanceSemantic proximity Read

Biogenesis of mature piRNAs in <i>Caenorhabditis elegans</i> is dependent on orchestration between multiple ribonucleases and PRG-1Semantic proximity Read

A role for the <i>C. elegans</i> Argonaute protein CSR-1b isoform in small nuclear RNA 3’ processingSemantic proximity Read

A family of <i>C. elegans</i> VASA homologs control Argonaute pathway specificity and promote transgenerational silencingSemantic proximity Read

GCNA preserves genome integrity and fertility across speciesSemantic proximity Read

Germline maintenance through the multifaceted activities of GLH/Vasa in <i>Caenorhabditis elegans</i> P granulesSemantic proximity Read

Germ granule compartments coordinate specialized small RNA productionSemantic proximity Read

Germ granule association drives small RNA specificity for a nuclear Argonaute proteinSemantic proximity Read