Article
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
Human molecular genetics - 1 Feb 2014
Chimusa Emile R, Zaitlen Noah, Daya Michelle, Möller Marlo, van Helden Paul D, Mulder Nicola J, Price Alkes L, Hoal Eileen G
Abstract excerpt
The worldwide burden of tuberculosis (TB) remains an enormous problem, and is particularly severe in the admixed South African Coloured (SAC) population residing in the Western Cape. Despite evidence from twin studies suggesting a strong genetic component to TB resistance, only a few loci have been identified to date. In this work, we conduct a genome-wide association study (GWAS), meta-analysis and trans-ethnic...
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