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Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.

Nature metabolism - 1 Feb 2026

Bocher Ozvan, Arruda Ana Luiza, Yoshiji Satoshi, Zhao Chi, Huerta-Chagoya Alicia, Su Chen-Yang, Yin Xianyong, Cammann Davis, Taylor Henry J, Chen Jingchun, Suzuki Ken, Mandla Ravi, Yang Ta-Yu, Matsuda Fumihiko, Mercader Josep M, Flannick Jason, Meigs James B, Wood Alexis C, Vujkovic Marijana, Voight Benjamin F, Spracklen Cassandra N, Rotter Jerome I, Morris Andrew P, Zeggini Eleftheria

Abstract excerpt

Type 2 diabetes (T2D) is a prevalent disease arising from complex molecular mechanisms. Here we leverage T2D genetic associations to identify causal molecular mechanisms in an ancestry-aware and tissue-aware manner. Using two-sample Mendelian randomization corroborated by colocalization across four global ancestries, we analyse 20,307 gene and 1,630 protein expression levels using blood-derived cis-quantitative...

Topics

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Diabetes Mellitus, Type 2
BAK1 gene
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Identifiers

PMID: 41593238
DOI: 10.1038/s42255-025-01444-1
PMCID: PMC12945685

Genes

BAK1
CPXM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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