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Ancestry-specific TWAS refines type 2 diabetes GWAS loci in disease-relevant tissues

2026-08-22

Abstract excerpt

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by hyperglycemia and insulin resistance. Although genome-wide association studies (GWAS) have identified >600 T2D risk loci, the causal genes and the relevant tissues mediating these associations remain largely unresolved. To address this challenge, we performed tissue-specific, ancestry-aware transcriptome-wide association studies (TWAS) across...

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Literature Corpus work
1ae105fb-6ee0-5415-9a89-d4569eb7f030
DOI
10.64898/2026.08.19.26360695
Open publication

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Ancestry-specific TWAS refines type 2 diabetes GWAS loci in disease-relevant tissuesDOI 10.64898/2026.08.19.26360695
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